XENLETA: the first and only
oral and IV pleuromutilin
antibiotic for CABP1,2

XENLETA is a systemic, empiric pleuromutilin antibiotic with activity against specific Gram-positive, Gram-negative, and other respiratory bacteria.1

Novel mechanism of action (MOA)

Novel mechanism of action (MOA)

as a pleuromutilin with a chemical structure
distinct from existing classes in CABP1

Low propensity for resistance

Low propensity for resistance

due to unique ribosomal binding
via multiple interactions1

XENLETA is different from older antibiotics

Some isolates resistant to β-lactams, macrolides,
quinolones, tetracyclines, and other treatments

may be susceptible to XENLETA1