Adverse reactions to
XENLETA were generally
mild to moderate regardless of
oral or IV administration1

3.3% (21/641) of patients taking XENLETA discontinued treatment due to adverse reaction vs 3.3% (21/641) of patients taking moxifloxacin2

Adverse reactions occurring in ≥2% of patients receiving XENLETA2

Adverse Reactions XENLETA
N=273
moxifloxacin ± linezolid
N=273
Administration site
reactionsa
7% 3%
Nausea 3% 2%
Hepatic enzyme
elevationb
3% 3%
Hypokalemia 3% 2%
Insomnia 3% 2%
Headache 2% 2%
Adverse Reactions XENLETA
N=368
moxifloxacin
N=368
Diarrhea 12% 1%
Nausea 5% 2%
Vomiting 3% 1%
Hepatic enzyme
elevationb
2% 2%
Adverse
Reactions
Trial 1
IV ± Oral Dosing
Trial 2
Oral Dosing Only
XENLETA
N=273
moxifloxacin ± linezolid
N=273
XENLETA
N=368
moxifloxacin
N=368
Diarrhea N/A N/A 12% 1%
Administration site
reactionsa
7% 3% N/A N/A
Nausea 3% 2% 5% 2%
Hepatic enzyme
elevationb
3% 3% 2% 2%
Hypokalemia 3% 2% N/A N/A
Insomnia 3% 2% N/A N/A
Vomiting N/A N/A 3% 1%
Headache 2% 2% N/A N/A
  1. aAdministration site reactions include infusion site pain, infusion site phlebitis, and injection site reaction.
  2. bHepatic enzyme elevation includes alanine aminotransferase increased, aspartate aminotransferase increased, and liver function test increased.

Total time on XENLETA can be as short as 5 days.2

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